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Faculty
Josef Neu, M.D.
Professor of Pediatrics; Director of Neonatology Fellowship Training Program
College
University of Wisconsin, Whitewater
Medical School
University of Wisconsin, Madison
Residency
Johns Hopkins
Fellowship
Stanford University
Number of years at UF as Faculty
24
Research Interests
- Developmental Gastroenterology
- Biochemical Nutrition of the Neonate
- Barrier Function of the GI tract
Active Research Projects/Grants
- Arginyl-Glutamine in the prevention of proliferative retinopathy
- Probiotics and Microbial Components in the Regulation of Intestinal Inflammation
- Intestinal Barrier Function and Pathogenesis of Type 1 Diabetes
- Early Nutrition and Adult Health
- Pathogenesis of Necrotizing Enterocolitis
- Development and Modulation of the Intestinal Microbiome
In past 5 years, have had NIH RO1 and RO3 funding as well as funding from Industry.
Selected Publications Since 2002
- Neu J. Gastrointestinal maturation and implications for infant feeding. Early Hum Dev. 2007 Oct 1; [Epub ahead of print]
- Neu J. Perinatal and neonatal manipulation of the intestinal microbiome: a note of caution. Nutr Rev. 2007 Jun;65(6 Pt 1):282-5. Review.
- Neu J. Arginine supplementation for neonatal necrotizing enterocolitis: are we ready? Br J Nutr. 2007 May;97(5):814-5.
- Neu J, Douglas-Escobar M, Lopez M Microbes and the developing gastrointestinal tract.
- Nutr Clin Pract. 2007 Apr;22(2):174-82. Review.
- Neu J. Gastrointestinal development and meeting the nutritional needs of premature infants.Am J Clin Nutr. 2007 Feb;85(2):629S-634S. Review.
- Neu J. Neonatal necrotizing enterocolitis: an update.
- Acta Paediatr Suppl. 2005 Oct;94(449):100-5.
- Neu J, Zhang L Feeding intolerance in very-low-birthweight infants: what is it and what can we do about it? Acta Paediatr Suppl. 2005 Oct;94(449):93-9.
- Caicedo RA, Schanler RJ, Li N, Neu J. The developing intestinal ecosystem: implications for the neonate. Pediatr Res. 2005 Oct;58(4):625-8. Review
- Neu J, Caicedo R. Probiotics: protecting the intestinal ecosystem? J Pediatr. 2005 Aug;147(2):143-6.
- Liu Z, Li N, Neu J. Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatr. 2005 Apr;94(4):386-93. Review
- Neu J, Chen M, Beierle E. Intestinal innate immunity: how does it relate to the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg. 2005 Aug;14(3):137-44. Review.
- Zhang L, Li N, Caicedo R, Neu J. Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor-alpha-induced interleukin-8 production in Caco-2 cells.J Nutr. 2005 Jul;135(7):1752-6.
- Neu J, Reverte CM, Mackey AD, Liboni K, Tuhacek-Tenace LM, Hatch M, Li N, Caicedo RA, Schatz DA, Atkinson M. Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes.J Pediatr Gastroenterol Nutr. 2005 May;40(5):589-95.
- Liboni KC, Li N, Scumpia PO, Neu J. Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium. J Nutr. 2005 Feb;135(2):245-51.
- Neu J. The 'myth' of asphyxia and hypoxia-ischemia as primary causes of necrotizing enterocolitis. Biol Neonate. 2005;87(2):97-8. Epub 2004 Nov 3.
- Li N, Lassman BJ, Liu Z, Liboni K, Neu J. Effects of protein deprivation on growth and small intestine morphology are not improved by glutamine or glutamate in gastrostomy-fed rat pups. J Pediatr Gastroenterol Nutr. 2004 Jul;39(1):28-33
- Beierle EA, Chen MK, Hartwich JE, Iyengar M, Dai W, Li N, Demarco V, Neu J. Artificial rearing of mouse pups: development of a mouse pup in a cup model. Pediatr Res. 2004 Aug;56(2):250-5
- Li N, Lewis P, Samuelson D, Liboni K, Neu J. Glutamine regulates Caco-2 cell tight junction proteins. Am J Physiol Gastrointest Liver Physiol. 2004 Sep;287(3):G726-33
- Liboni K, Li N, Neu J. Mechanism of glutamine-mediated amelioration of lipopolysaccharide-induced IL-8 production in Caco-2 cells. Cytokine. 2004 Apr 21;26(2):57-65.
- Tuhacek LM, Mackey AD, Li N, DeMarco VG, Stevens G, Neu J Substitutes for glutamine in proliferation of rat intestinal epithelial cells. Nutrition. 2004 Mar;20(3):292-7.
- Li N, Liboni K, Fang MZ, Samuelson D, Lewis P, Patel R, Neu J. Glutamine decreases lipopolysaccharide-induced intestinal inflammation in infant rats. Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G914-21
- Neu J. Glutamine supplements in premature infants: why and how. J Pediatr Gastroenterol Nutr. 2003 Nov;37(5):533-5.
- Neu J, Huang Y. Nutrition of premature and critically ill neonates. Nestle Nutr Workshop Ser Clin Perform Programme. 2003;8:171-81; discussion 181-5. Review.
- Li N, DeMarco VG, West CM, Neu J. Glutamine supports recovery from loss of transepithelial resistance and increase of permeability induced by media change in Caco-2 cells. J Nutr Biochem. 2003 Jul;14(7):401-8.
- Huang Y, Li N, Liboni K, Neu J. Glutamine decreases lipopolysaccharide-induced IL-8 production in Caco-2 cells through a non-NF-kappaB p50 mechanism. Cytokine. 2003 May;22(3-4):77-83.
- DeMarco VG, Li N, Thomas J, West CM, Neu J. Glutamine and barrier function in cultured Caco-2 epithelial cell monolayers. J Nutr. 2003 Jul;133(7):2176-9.
- Vaughn P, Thomas P, Clark R, Neu J. Enteral glutamine supplementation and morbidity in low birth weight infants. J Pediatr. 2003 Jun;142(6):662-8.
- Clark RH, Wagner CL, Merritt RJ, Bloom BT, Neu J, Young TE, Clark DA. Nutrition in the neonatal intensive care unit: how do we reduce the incidence of extrauterine growth restriction? J Perinatol. 2003 Jun;23(4):337-44. Review.
- Huang Y, Shao XM, Neu J. Immunonutrients and neonates. Eur J Pediatr. 2003 Mar;162(3):122-8. Epub 2003 Jan 31. Review.
- Neu J, Auestad N, DeMarco VG. Glutamine metabolism in the fetus and critically ill low birth weight neonate. Adv Pediatr. 2002;49:203-26.
- Potsic B, Holliday N, Lewis P, Samuelson D, DeMarco V, Neu J. Glutamine supplementation and deprivation: effect on artificially reared rat small intestinal morphology. Pediatr Res. 2002 Sep;52(3):430-6.
- Patel MR, DeMarco VG, Clare-Salzler M, Li YY, Neu J. Indomethacin, dexamethasone, and intestinal damage in infant rats. J Pediatr Gastroenterol Nutr. 2002 Aug;35(2):154-61
- Neu J. Arginine supplementation and the prevention of necrotizing enterocolitis in very low birth weight infants. J Pediatr. 2002 Apr;140(4):389-91.
- Neu J, Bernstein H. Update on host defense and immunonutrients. Clin Perinatol. 2002 Mar;29(1):41-64. Review.
- Neu J, DeMarco V, Li N. Glutamine: clinical applications and mechanisms of action. Curr Opin Clin Nutr Metab Care. 2002 Jan;5(1):69-75. Review.
Other Clinical Interests
- Organization of Neonatal Program Directors Board and Chairman
- Council of Pediatric Subspecialties (CoPS)
